Acute toxicity oftrans-5-hydroxy-2-nonenal in fisher 344 rats
نویسندگان
چکیده
منابع مشابه
Synaptosomal Toxicity and Nucleophilic Targets of 4-Hydroxy-2-Nonenal
4-Hydroxy-2-nonenal (HNE) is an aldehyde by-product of lipid peroxidation that is presumed to play a primary role in certain neuropathogenic states (e.g., Alzheimer disease, spinal cord trauma). Although the molecular mechanism of neurotoxicity is unknown, proteomic analyses (e.g., tandem mass spectrometry) have demonstrated that this soft electrophile preferentially forms Michael-type adducts ...
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Although 4-hydroxy-2-nonenal (HNE, a product of lipid peroxidation) is a major cause of oxidative damage inside skeletal muscles, the exact proteins modified by HNE are unknown. We used two-dimensional electrophoresis, immunoblotting, and mass spectrometry to identify selective proteins targeted by HNE inside the diaphragm of rats under two conditions: severe sepsis [induced by E. coli lipopoly...
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ژورنال
عنوان ژورنال: Lipids
سال: 1993
ISSN: 0024-4201,1558-9307
DOI: 10.1007/bf02537511